Exhibit 5.1

March 23, 2022

Consent of Independent Registered Public Accounting Firm

We hereby consent to the incorporation by reference in this Amendment No. 1 to the Registration Statement on Form F-10 (No. 333-263248) of Profound Medical Corp. (the Company) of our report dated March 3, 2022, which appears in Exhibit 99.3 to the Company’s Form 40-F for the year ended December 31, 2021.

/s/PricewaterhouseCoopers LLP

Chartered Professional Accountants, Licensed Public Accountants

Oakville, Ontario, Canada

PricewaterhouseCoopers LLP 

PwC Centre, 354 Davis Road, Suite 600, Oakville, Ontario, Canada L6J 0C5 

T: +1 905 815 6300, F: +1 905 815 6499, www.pwc.com/ca

“PwC” refers to PricewaterhouseCoopers LLP, an Ontario limited liability partnership.